الفهرس 
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Abstract
Evaluation of human health effects (immediate and delayed) after exposure to chronic low dose and dose rate has proven to be technically challenging for many decades. Current radiation biodosimetry approaches include physical effects such as blood lymphocyte kinetics and time to emesis, as well as assessing chromosome aberrations in biodosimetry of cytogenetic which induced by radiation in circulating blood lymphocytes.
This current study demonstrates the abtility of using biodosimetry of gene/protein expression levels of XPC biomarker among Radiation Workers by using qRT-PCR and ELISA. And also established to detect transcriptional and translational differences of it after external high/low dose rates irradiation.
The gene expressions of (XPC) Xeroderma Pigmentosum Complementary in the whole blood was assayed using qRT-PCR technique among 71 blood samples, and also XPC protein was assayed by ELISA technique among 81 samples. divided into 3 main groups (healthy control, radiation workers, cancer patients).
When assessing the acute radiation exposure (radiotherapy), The relative expression of the circulating XPC is down regulated in the patients after radiotherapy (related to pre-radiotherapy). Also, when the circulating XPC relative expression measured over the control subjects in occupational workers it was slightly downregulated among the radiation workers to 0.9083 ± 1.4802 folds, which represents its differentiated behavior in different dose rates.
According to XPC protein levels expression, there was a statistically significant difference between the three studied groups. The decreasing in its expression levels after irradiation with high dose rates (in post-radiotherapy group) and increasing in its expression levels among low dose rates exposed workers (occupational workers group). Finally, XPC protein can discriminate workers from control group with a sensitivity of about 89%, specificity about 76%, the cutoff value is 7.04 and the area under the curve is 83%. Which explain the efficacy of the XPC protein as an efficient monitoring biomarker in low dose rates (among radiation workers).