الفهرس 
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Abstract
Osteoporosis is common in both women and men with increasing age. Fragility fractures are associated with increased mortality and osteoporosis medication use reduces mortality risk in men and women.
Although overt hyperthyroidism and overt hypothyroidism have been linked to osteoporosis in both women and men, it is unclear whether subclinical thyroid dysfunction, in which TSH levels are altered but thyroid hormone levels are in the reference range, has a negative effect on bone.
The finding that TSH acts directly on bone supports the idea that subclinical thyroid dysfunction may also confer risk of low bone density and fracture. Some studies of older or middle-aged adults suggest that TSH concentration is associated with bone mineral density (BMD) or fracture risk but other reports found discrepant results.
In this study we enrolled a total of 20 patients with SCH and 20 healthy subjects to study the BMD in patients with SCH in comparison to normal population. Also, to evaluate the association between thyroid function parameters and bone densitometry.
The main findings of the current study were; 1) patients with SCH had significantly lower BMD (0.872 ± 0.123 vs. 0.991 ± 0.112 (g/cm); p= 0.003), T-score (−2.53 ± 0.618 vs. −0.392± 1.03; p< 0.001) and Z-score (−0.6 ± 1.36 vs. −0.2 ± 1.2; p< 0.001), 2) Patients SCH had had significantly lower vitamin D (14.98 ± 6.62 vs. 34.68 ± 13.92 (ng/ml); p< 0.001) and significantly higher TC (184.89 ± 25.91 vs. 165.78 ± 23.67 (mg/dl); p= 0.02) and LDL (114.8 ± 29 vs. 94.78 ± 17.54 (mg/dl); p= 0.012).
Also, we found that 12 (60%) patients had no osteopenia and osteoporosis while 2 (10%) patients had osteopenia and 6 (30%) patients had osteoporosis. There is a significant positive correlation between BMD and FT4 and FT3 while there is a significant negative correlation between BMD and TSH. At cutoff point; TSH > 9.45; had 95% accuracy for prediction of bone mineral disorders in patients with SCH with area under curve was 0.939