الفهرس 
MULTISYSTEM INFLAMMATORY SYNDROME IN CHILDREN (MIS-C)Only 14 pages are availabe for public view
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Abstract
ABSTRACT
Background: Multisystem inflammatory syndrome in children (MIS-C) is a dysregulated immune response to viral infection by COVID-19 accompanied by systemic manifestations. Macrophage migration inhibitory factor (MIF) exerts inhibitory effects on macrophage migration and is raised in adult cardiac critical illness
Purpose: To identify the role of MIF as a marker of cardiac affection in MIS-C patients.
Patients and Methods: This case- controlled study was conducted on 20 MIS- C children and 20 apparently healthy controls. Clinical and laboratory data were compared between both groups. Echocardiography was done for all participants.
Results: Myocardial injury markers as troponins, CK- MB and liver injury markers were significantly (p>0.05) elevated among MIS- C patients than controls. MIF expression was also significantly higher (p>0.05) among MIS- C patients. Impaired LV function and valve regurgitation were the main echocardiographic findings among MIS- C patients. MIF correlated significantly with age, lymphocytic count, ferritin, LDH, D- dimer, CK- MB, EF%, LVESD, LVEDD, Z-score RCA and Z-score LCA.
Conclusion: Myocardial injury is common in MIS- C patients. Impaired LV function is the most prominent echocardiographic finding. MIF could be considered as a biomarker for MIS- C and correlated significantly with myocardial affection among those patients.