الفهرس 
Ketogenic DietOnly 14 pages are availabe for public view
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Abstract
Background: The ketogenic diet (KD), a high-fat, low-carbohydrate, adequate-protein diet is an established, effective non-pharmacological treatment for children with intractable epilepsy. Relatively few serious complications have been reported in the more than 70 years in which the diet has been used.
Aim of the Work: to highlight ketosis during ketogenic diet therapy and amylase/lipase levels as an indicator for pancreatic affection.
Patients and Methods: This is a prospective observational (pilot) study conducted at clinical nutrition unit, Ain Shams university children’s hospital, Cairo, Egypt during the period from September 2022 to October 2023 aiming to highlight ketosis during ketogenic diet therapy and amylase/lipase levels as an indicator for pancreatic affection.
Results: Serum amylase and lipase levels in Ketogenic diet group increased in 3 month interval(p value <0.001) to be significantly higher than baseline, and then decreased in 6 month interval, but was non-significantly higher than baseline. Serum amylase and lipase levels was higher among Ketogenic diet group in 3 month interval and in 6month interval, but the differences were significant only in 3 month interval.(p value 0.017),(pvalu 0.015) respectively. lipid profile follow up revealed serum cholesterol, triglyceride , LDL levels in Ketogenic diet group increased in month-3 to be significantly higher than baseline (P=0.004 ) ,(P=0.022 ), (P= <0.001) respectively, then decreased in month-6, ( P=0.6020), ( P =0.925 ) , (P = 0.198 ) respectively. Serum cholesterol, triglyceride, LDL level were higher among Ketogenic diet group in month-3 and month-6, but the differences were significant only at 3 month interval. (Pvalu 0.004), (P value 0.022), (p-value <0.001) respectively. While serum HDL level following showed no statistical significant differences between the studied groups regarding month-3 (P =0.230) and month-6 (P = 0.507).
Conclusion: Our study found that a ketogenic diet (KD) in children with drug-resistant epilepsy led to significant increases in serum amylase, lipase, and lipid levels, particularly in the first three months. Although no cases of pancreatitis were observed, close monitoring and further research are needed to assess the long-term safety of KD in this population.