الفهرس 
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Abstract
Polycystic ovary syndrome is the most prevalent endocrinal disease in women, its incidence 4-15%.
PCOS happens due to genetic, environmental, physiological changes to the women who are at risk of developing the syndrome.
These women suffer the risks of obesity, insulin resistance, glucose intolerance, dyslipidemia, and infertility due to hyperandrogenism, menstrual irregularities and ovulatory dysfunction because of these changes.
These women are suffering from hyper-estrogenemia which increases the risk of developing cardiovascular problems, endometrial hyperplasia, and endometrial cancer.
Hyperandrogenemia causes hirsutism and acne which causes another psychological problem of the disease.
In a healthy woman, each month several follicles are recruited and, only one of them becomes the dominant follicle and undergo many physiological changes to increase in size, reach about 18 mm, to be eligible for ovulation then fertilization.
In PCOS the recruited follicles in each cycle cease to grow to at early stages of the cycle, with the arrested follicles arranged at the periphery of the ovary giving the ovary a string of pearls appearance.
As a result of this these women suffer anovulation, amenorrhea, and irregular menses.
To diagnose PCOS we follow the Rotterdam criteria/2003 2 of the following criteria should be present: Androgen excess, Ovulatory dysfunction, and PCOM.
Treatment of PCOS:
1. Lifestyle modification.
2. Medical treatment:
• Combined oral contraceptives, to regulate menses in women who don’t desire fertility.
• Insulin resistance &Hyperandrogenemia: Metformin.
• Infertility medications: clomiphene citrate, Letrozole…etc.
3. IVF treatment.
4. Laparoscopic ovarian drilling.
In IVF treatment has a pregnancy success rate of 60-7-% in PCOS women, by using different GnRH-agonist or antagonist protocols for ovulation induction.
Women with PCOS respond well to IVF treatment. These women can respond too well to stimulation, making them under a risk of risk of developing Ovarian Hyperstimulation Syndrome (OHSS). This is a