الفهرس 
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Abstract
I
nhalation injury refers to an acute respiratory tract injury resulting from the inhalation of steam or toxic substances like fumes, gases, and mists. While it can happen independently of cutaneous burn injury, inhalation injury typically accompanies burns.
Nebulized heparin exerts a local anticoagulant effect in the lungs without significant systemic effects and can mitigate pulmonary coagulopathy in critically ill patients. Heparin helps decreasing inflammation.
The study aimed to examine the value of nebulized heparin for prevention of acute lung injury in adult patients suffering smoke inhalation injury.
This Randomized controlled double–blind study was carried out on 88 patients indicated for elective intubation at Ain shams university hospitals burn ICU.
The current study findings indicate that while inhaled heparin was linked to an elevated P/F ratio, it did not decrease the occurrence of severe acute respiratory distress syndrome (ARDS), but rather postponed its onset. Additionally, inhaled heparin did not affect the overall mortality rate, although it was correlated with a shorter survival duration. Regarding side effects, inhaled heparin was associated with reduced platelet count and prolonged partial thromboplastin time (PTT). However, these effects were not clinically significant, as the incidence of thrombocytopenia and prolonged PTT was similar in both groups.
CONCLUSION
N
ebulized heparin was associated with improved oxygenation but was did not reduce the incidence of severe ARDS, failed weaning from mechanical ventilation or mortality in patients suffering inhalation injury. Nebulized heparin had no effect on prothrombin time but could be associated with clinically unimportant reduction in platelet count.
RECOMMENDATIONS
F
urther confirmation of our findings is warranted through additional clinical research involving larger sample sizes, higher doses of nebulized heparin and longer follow up to thoroughly assess its safety and efficacy for prevention of acute lung injury in adult patients suffering smoke inhalation injury.