الفهرس 
CHILDREN INTERSTITIAL LUNG DISEASEOnly 14 pages are availabe for public view
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Abstract
Childhood interstitial lung diseases (chILD) refer to a rare heterogeneous group of disorders associated with significant morbidity and mortality, characterized by abnormalities of the distal lung units and disordered gas exchange (Ferraro et al., 2020).
The large number of disorders in chILD, in combination with the rarity of each diagnosis, has hampered scientific and clinical progress within the field. Epidemiologic and natural history data are limited. The prognosis varies depending on the etiology, with some forms progressing to lung transplant or death (Deterding et al., 2019).
Since the process of angiogenesis has been implicated in the pathogenesis of fibrotic lung diseases, vascular endothelial growth factor (VEGF) has been recognized as a major regulator of normal and pathological angiogenesis and as an enhancer of vascular permeability (Alsohaimi, 2019).
The aim of this study was to measure the level of VEGF in serum among chILD patients and determine its relation to the clinical and radiological severity .
This cross sectional study has been conducted at Pediatric pulmonology clinic; Ain Shams University Children’s Hospital located in Cairo during the period from January 2022 to June 2023.The study included 45 chILD patients compared to 40 sex- and age-matched healthy controls recruited form Pediatric General Clinic; Children’s Hospital, Ain Shams University