الفهرس 
Introduction and Aim of the workOnly 14 pages are availabe for public view
 |  | from | 128 |  |  |
| | | from | 128 | | |
Abstract
Perinatal asphyxia is a common cause of neonatal morbidity and mortality and neurologic disabilities among survivors. It is important to find early and reliable indicators of brain damage or of poor long-term prognosis to initiate or end neuroprotective treatment. Brain-specific proteins have been used to detect cerebral injury after birth asphyxia. Neuron-specific enolase (NSE) is capable of identifying newborns with a risk of developing hypoxic-ischemic encephalopathy. The presence of elevated NSE values in serum after perinatal asphyxia can be a sensitive indicator of conspicuous brain damage and high predictive value for neurological outcome.
Objective:
This work aims to asses if NSE can be used as a serum biochemical marker of brain damage in the newborn exposed to perinatal asphyxia and also to study the correlation between cord blood serum NSE levels and neurological outcome in newborns with hypoxic-ischemic encephalopathy after follow up at 6 mo and 12 mo.
Study design:
This study was carried out on 50 neonates who were delivered in the Obstetric Unit of Zagazig University Hospitals and admitted to the Neonatal Intensive Care Unit (NICU).
The patient group comprised thirty full term newborns who developed symptoms and signs of HIE according to Sarnat and Sarnat (group I).
The asphyxia group was subdivided according to the clinical examination into three grades:
1. No or mild HIE (HIE-I).
2. Moderate HIE (HIE-II).
3. Severe HIE with a greater risk of neural handicap (HIE-III).
Twenty full-term infants of matched age, sex and weight with normal physical findings were included as the control group (group II).