الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Psoriasis is an autoimmune inflammatory disease of the skin and musculoskeletal system, as about 30% of patients with psoriasis eventually develop psoriatic arthritis (PsA). Atherosclerosis is a common condition that develops in psoriatic arthritis patients, as inflammation plays an important role in all stages of the atherosclerotic process. Inflammation acts as a common basis for the pathological changes throughout atherosclerosis initiation and development. Musculoskeletal Ultrasound can aid the assessment of disease where clinical assessment may have missed underlying occult PsA disease activity. As well as for disease monitoring, remission status, and disease activity measures. MSUS can aid the assessment of atherosclerosis by detection of carotid intima media thickness (CIMT) & flow mediated dilatation (FMD) of brachial artery. So, this study was conducted to diagnose subclinical atherosclerosis in psoriatic arthritis patients by the following methods (carotid intima media thickness, flow mediated dilatation of brachial artery). Also, detect their correlation with disease activity & severity. Sixty Patients full fill CASPAR criteria for psoriatic arthritis and sixty control subjects; Patients who were hypertensive, diabetic, had chronic renal disease (creatinine >1.3 mg/dl), obesity with BMI > 30 kg/m2. History cardiovascular of and/or cerebrovascular disease, Other systemic& rheumatic diseases were excluded. All participants were subjected to complete history taking, complete clinical examination (the disease activity was assessed according to the DAPSA, function assessment by PsAQol & ASCVD risk score estimation), laboratory investigation (ESR, CRP, CBC, Serum uric acid, total cholesterol, triglycerides, HDL, LDL, VLDL) and musculoskeletal ultrasound for detection of CIMT, FMD & PsASOn22.