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Abstract Acute kidney injury (prerenal and renal AKI) are the various phenotypes of acute kidney injury, which are described in decompensated cirrhosis. It has therapeutic and prognostic implications. We aimed to evaluate the diagnostic utility of fractional excretion of sodium and urea (FENa and FEUrea) for differentiating AKI phenotypes. A prospective analysis was performed in 150 patients AKI and non-AKI to differentiate renal and prerenal AKI. The occurrence of prerenal AKI, and renal AKI were 89%, and 11% in the derivation cohort. The mean FENa was significantly different in various phenotypes of AKI in the derivation and validation cohort (P 0.001); Concerning the gender distribution in this study, male to female percent was 102 (68%) males and 48 (32%) females for gender, respectively. As regards to the causes of AKI, there were (89%) prerenal AKI, and (11%) renal AKI for final diagnosis. In the current study, there was significant difference (P=0.0001; P < 0.05) in FEurea % among pre-renal groups (27.16 ±16.17). Findings showed a higher AUC FEUrea% 0.911 compared to AUC FENa% 0.888. |