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Abstract The human papilloma virus (HPV) is a 55-nm DNA virus that belongs to the parvovirus family. it infects skin and mucosal membranes and replicates in the nuclei of infected epithelial cells. HPV consists of 70 distinct types, of which 34 are associated with anogenital lesions. Genital warts, are papillomata’s, pedunculated, or sessile growths that can grow anywhere on anogenital skin. Single lesions are usually 1 to 4 mm in diameter. Condylomata are usually flesh-colored, but may be pigmented or erythematous. Intraepithelial neoplasia occurs on the vulva, vagina, cervix, or penis. Bowenoid papulosis occurs more frequently in hyperpigmented lesions and may be interspersed with multiple condylomata. Progression to invasive squamous cell carcinoma can occur, particularly in immunosuppressed individuals. Large lesions are called giant condylomata of Buschke and Löwenstein. HPV is one of the most common sexually transmitted diseases in the world, and anogenital warts are one of its various clinical manifestations. It is estimated that between 3 and 4 million men worldwide are diagnosed with genital warts each year. it is transferred by skin-to-skin sexual contact and is accompanied with and without clinical lesions. Genital warts (GWs) are common among sexually active persons. Although symptoms are in general mild, genital warts are commonly perceived as a non-serious condition, treatment is often long, of varying effectiveness and the recurrence rate is high, It has been shown that anogenital warts influence psychological status, decreased emotional well-being has been reported among persons with genital warts compared to persons without genital warts. Like many sexuallytransmitted infections (STIs) GWs were associated with a negative impact on health-related quality of life. Male patients with GWs have increased rates of anxiety, depression and sexual dysfunction, Many people with genital warts feel stigmatized by their condition, blame themselves, and worry that the infection may be transmitted to a partner. They may also be concerned that a new partner will reject them when they explain their situation. Men who have multiple genital warts are more likely to have higher rates of sexual dysfunction, depression, and anxiety. It has been reported that patients with GWs have increased levels of several cytokines such as tumor necrosis factor, interleukin 4 and interleukin 10 that may induce anxiety in the brain. The study was aiming to assess the potential impact of multiple genital warts on the sexual function of men affected by such lesions. This case control study included 40 male patients having multiple genital warts. patients were collected from Dermatology and Venereology clinic of Menoufia University Hospital, in addition to 40 healthy subjects of matched age and sex as controls. |