الفهرس 
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Abstract
Acne vulgaris is a chronic inflammatory disorder of the pilosebaceous unit that affects predominantly adolescents and young adults. It is characterized by noninflammatory, open or closed comedones and inflammatory papules, pustules, and nodules. It results from androgen-induced increased sebum production, altered keratinization, inflammation, and bacterial colonization of hair follicles by Propionibacterium acnes.
Patients with post-adolescent acne appear to represent an increasingly important population of acne sufferers. External factors do not seem to have a significant aetiological role. Two main clinical groups were identified: those with persistent acne and those with late-onset acne. A minority of women also had features of hyperandrogenicity. These patients, and those with late-onset acne, may represent a subgroup who have underlying abnormalities of ovarian, adrenal or local androgen metabolism, and require separate investigation.
Clusterin (apolipoprotein J) is a 75 - 80 kDa disulfide-linked heterodimeric protein associated with the clearance of cellular debris and apoptosis. In humans, clusterin (CLU) is encoded by the CLU gene on chromosome 8. CLU is a molecular chaperone responsible for aiding protein folding of secreted proteins, and its three isoforms have been differentially implicated in pro- or antiapoptotic processes.
It was revealed that serum clusterin levels were higher in subjects with metabolic syndrome than in those without metabolic syndrome.
The aim of this study was to assess the level of serum clusterin in patients with post-adolescent acne and its possible relation with the severity of the disease.
This Case control study was conducted on 50 patients suffering from post-adolescent Acne (group A). In addition, 30 apparently healthy individuals were chosen as a control group (group B). All patients and control group were subjected to lab investigations (complete lipid profile and serum levels of clusterin).
Summary of this results:
• The current study included 50 patients with post-adolescent acne, their mean age was (33.22 ± 4.3) years and 30 control subjects were selected to be matched in age, with a mean age of (32.73 ± 3.68) years. And regarding sex, they were selected to be matched, 24% of patients were females, 76% males and the control included 26.7% females and 73.3% males.
• BMI, systolic blood pressure and diastolic blood pressure were significantly higher in the patient group than control group. There was no significant differences between studied groups regarding waist circumference.
• Among all studied patients, 66% had positive family history of post-adolescent acne. Mean duration of illness in patients with post-adolescent acne was 9.28 months. Median duration of disease in patients with post-adolescent acne was 10.
• According to Global acne grading system (GAGS), eighteen patients (36.0%) were graded as mild, twenty-one (42.0%) graded moderate, seven patients (14.0 %) were graded severe, and four patients (8.0 %) graded very severe.
• There were no significant differences between patients and control groups regarding laboratory data (FBG, TC, TG, HDL and LDL).
• Serum Clusterin level was significantly higher in patients with post-adolescent acne (p=0.001*) when compared to the control (mean=41.8 versus 33.62), (median=41.09 versus 33.9).