الفهرس 
REVIEW OF LITERATUREOnly 14 pages are availabe for public view
 |  | from | 139 |  |  |
| | | from | 139 | | |
Abstract
Microbial resistance to antibiotics is one of the most problematic issues for public health. Microbial resistance to antibiotics is one of the most problematic issues for public health because of the massive use of antibiotics prophylactically or remedially that generated resistant bacteria strains. Accordingly, we must stress the importance of discovering new drugs that have antimicrobial properties or shows synergic viability with drugs is very important nowadays.
In this study, Titanium Dioxide Nanoparticles (TiO2NPs) sample was acquired from Nanotech company at Egypt. The size and morphology of nanoparticles were estimated using a scanning electron microscope, Transmission electronic microscope and the dynamic light scattering (DLS) technique. TiO2NPs exhibited smooth and regular particles in the form of clusters with average size 15 ± 2 nm.
The antibiotic sensitivity of various classes of antibiotics against pathogenic Streptococcus pyogenes and Pseudomonas putida strains which collected from nanobiotechnology laboratory, Department of biochemistry, college of science, Tikrit University and were identified by vitek2 system.
This study was designed to investigate the role of titanium dioxide nanoparticles TiO2NPs, and silymarin against inflammatory reactions in rats induced by bacteria. Thirty-six male rats were used in the experimental study. four rats represent the healthy control group (CTRL), the remain were separated into two main groups, the first group was infected by Streptococcus pyogenes, and the second group was infected by Pseudomonas putida. Each main group was divided into 3 subgroups as follows: the first represented the infected and treated by TiO2NPs (T), the second group the infected and treated by Silymarin (S) and the third group represent the infected and treated by combination of TiO2NPs and silymarin (TS), For seven days.
Results demonstrated that infection of rats with St. pyogenes resulted in increase in level of liver enzymes, antioxidants enzymes and levels of inflammatory mediators. On the other hand, treatment with silymarin and TiO2NPs resulted in alleviation of effect of infection with bacteria.
The microbiome of the guts of rats infected by St. pyogenes and P. putida and treated with a combination of TiO2NPs and silymarin were examined, results showed increase in the numbers of lactobacillus as a result of oral administration of TiO2NPs and silymarin.