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العنوان
Synthesis and Biological Evaluation of New Dithiocarbamate Derivatives and New α- aminophosphonate Conjugates Containing Heterocyclic Nucleus/
المؤلف
Ghanim, Ibrahim Mohammed Abdelmotaleb
هيئة الاعداد
مشرف / Ibrahim Mohammed Abdelmotaleb Ghanim
مشرف / Prof. Dr. Abdel Aleem Hassan Abdel Aleem
مشرف / Prof. Dr. Ahmed Abdel Aleem Hassan
مناقش / Prof. Dr. Ahmed Abdel Aleem Hassan
الموضوع
eactions of Phthalazines Synthesis of Fused Phthalazine Derivatives
تاريخ النشر
2023
عدد الصفحات
193 P. :
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
Organic Chemistry
تاريخ الإجازة
1/8/2022
مكان الإجازة
جامعة المنوفية - كلية العلوم - قسم الكمياء
الفهرس
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Abstract

Phosphorus, sulpher and heterocyclic nuclei have a real significant role in medicinal
chemistry, so our inspirations headed and focused on α-aminophosphonates and
dirhiocarbamate and heterocyclic nuclei (triazine and phthalazine). According to this
thesis work, synthesis and biological evaluation of new dithiocarbamate derivatives and new α-aminophosphonate conjugates containing heterocyclic nucleus is dealt with. We started our thesis in the first chapter with introduction about the synthesis, properties and applications of α-aminophosphonates as the major subject for this
thesis, dithiocarbamates and heterocyclic nuclei (triazine and phthalazine). We also
discuss the synthesis of new dithiocarbamate derivatives, triazine derivatives,
phthalazine derivatives and their all α-aminophosphonate conjugates in the second chapter, then we also affirm these synthesized compounds with characterization by different spectroscopic analysis and also test their biological properties against gram-positive bacteria, gram-negative bacteria and fungi infections. The details of the general experimental procedures and spectroscopic analysis data of all >synthesized compounds are described in this thesis.