الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Cases of Fungal keratitis are still considered challenging to ophthalmologists due to the difficulties in management of such cases, starting from the availability of and susceptibility to antifungal agents, to penetration of corneal tissues, as fungal pathogens tend to deeply penetrate corneal tissues and may reach the anterior chamber. Topical antifungal alone or combined with oral antifungal medications seems to be effective in the early stages of the keratitis. Targeted drug delivery has the potential to achieve sufficient drug concentrations at the site of infection and serve as an alternative modality of treatment in eyes with recalcitrant fungal keratitis. Among the targeted drug delivery modalities, intrastromal injection of antifungal agents has shown promising results. In order to achieve adequate intracorneal concentrations of antifungals, intrastromal injections of antifungals have been tried. Fluconazole is mainly a fungistatic drug with broad spectrum activity as it is effective against Yeast & Dermatophytes (Candida, Cryptococcus neoformans & Aspergillus species). The aim of this study was to evaluate the safety and the efficacy of intrastromal injection of Fluconazole in the treatment of fungal keratitis.