الفهرس 
Mismatch NegativityOnly 14 pages are availabe for public view
 |  | from | 109 |  |  |
| | | from | 109 | | |
Abstract
Temporal lobe epilepsy (TLE) is a chronic disorder of the nervous system which is characterized by recurrent, unprovoked focal seizures that originate in the temporal lobe of the brain and last about one or two minutes. TLE is the most common form of epilepsy with focal seizures. Temporal lobe epilepsy (TLE) is often associated with memory impairment due to damage in the hippocampus and surrounding structures. It has been repeatedly shown that both short-term and long-term memories are impaired in TLE. However, little is known concerning dysfunction in initial sensory memory encoding in TLE.
The mismatch negativity (MMN) is an endogenous event related potential that is generated when an auditory stimulus deviates in some way from recent stimuli that were similar to each other .Mismatch negativity, an electrophysiological measure that evaluates the brain’s capacity to discriminate sounds, regardless of attentional and behavioral capacity. Thus, this auditory event-related potential is promising in the study of the neurophysiological basis underlying auditory processing.
The aim of this study was to assess the cognitive function in children with TLE using mismatch negativity and to compare MMN in children with TLE with normal children.
The study group (TLE group) included 22 children, recruited from the pediatric neurology clinic diagnosed by pediatric neurologist as temporal lobe epilepsy in the age range of (4-12 years). The control group consisted of 22 normal children in the age range of (4-12 years), selected from the relatives of the children in the study group living within the same regions.
Summary
61
The included patients were submitted to complete history taking, Physical and neurological assessment, IQ assessment, otoscopic examination, audiological evaluation, MMN evaluation. In the current study, there was statistically significantly difference between the studied groups regarding MMN latency and amplitude. MMN latency in TLE group was found to be more prolonged compared to that of the control group. Also, MMN amplitude in almost all the TLE group was found to be lower than that of the control group. Abnormal MMN tests (either prolonged latency or reduced amplitude) were obtained in almost TLE patients ≈ 90.9 % of TLE cases. The results demonstrate that there is auditory processing dysfunction in TLE cases which was proved by abnormalities in the MMN test.