الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 150 |  |  |
| | | from | 150 | | |
Abstract
The ubiquitous emergence of bacterial resistance is a challenging problem in infectious diseases treatment. Recently, new research lines employed nano-drug delivery systems to enhance antibacterial activity of the existing antibiotics. Accordingly, the objective of this study is to optimize surfactant nanovesicles to improve the antimicrobial effect of meropenem, ertapenem and tigecycline against Carbapenemase Resistant Enterobacteriaceae (CRE) and Extended Spectrum βeta-Lactamases producing bacteria (ESBL). Klebsiella pneumoniae and Escherichia coli were used as the test organisms and were collected total 110 isolates from different specimens. To achieve this objective niosomal formulation was selected as a nano-drug delivery system. For determining the resistance pattern of bacterial isolates different techniques were applied.