الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
 |  | from | 119 |  |  |
| | | from | 119 | | |
Abstract
Knee osteoarthritis (KOA) is a chronic degenerative joint disease associated with pain, disability and decreased quality of life. Recent research has investigated the potential role of human microbiota in the initiation and/or the progression of KOA pathology. Gut microbiota and its metabolites as lipopolysaccharides (LPSs) were associated with KOA severity and pain.
It was suggested that high fat diet and obesity induce gut dysbiosis with decreased microbial diversity. Gut dysbiosis is associated with increased gut permeability with the release of microbial DNA and LPSs into the circulation inducing a low grade systemic inflammation with the release of inflammatory cytokines that reach inside the knee joint.
from the literature review and clinical practice, most studies focused on gut microbiome (in stool) in relation to KOA, only a few focused on assessing them inside the knee joint specific tissues (synovial fluid (SF) and cartilage) and only one study assessed them in blood of KOA patients. Future studies should adopt a more site specific prospective search for the microbiome in knee joint specific tissues for better understanding of the role of microbiome in KOA.
The aim of this study was to detect human microbiome in the blood and SF of primary KOA patients and investigate their relation to the severity of KOA and knee pain.
The current study included 40 patients diagnosed with primary KOA with effusion and 40 age, sex and body mass index (BMI) matched healthy controls.