الفهرس 
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Abstract
This study was done for the assessment of serum neutrophil gelatinase-associated lipocalin in sepsis in the pediatric intensive care unit of Minia University Hospital.
It was carried out on 75 patients suffering from sepsis and 25 apparently healthy children. Our patients were taken from the pediatric intensive care unit, pediatrics department, Maternity & Children Hospital, Minia University in a period from September 2022 to March 2023. Our Patients were divided into:
group I: It includes 75 children suffering from sepsis (36 males and 39 females). Their ages ranged from 1 to 12 years. Patients in this group were subdivided into:
group I.A: 25 children with sepsis.
group I.B: 25 children with severe sepsis
group I.C: 25 children with multi-organ failure.
group II: It includes 25 children apparently healthy (12 males and 13 females). Their ages ranged from 1 to 12 years.
The studied groups were subjected to the following:
1) Careful history taking and clinical examination.
2) Laboratory investigations:
C. Routine investigations: as
Complete blood count (CBC).
Random blood sugar.
Renal Function Tests. (urea &creatinine).
ALT& AST&TB&DB
Prothrombin time and concentration (PT, PC) &PTT.
Blood culture
Electrolytes (sodium, potassium, calcium)
C reactive protein (CRP)
D. Special investigations: Determination of serum Neutrophil gelatinase-associated lipocalin by ELISA technique.
The results of this study were summarized as follows:
In our study, the ages of children ranged from 1-year to12 years. The multiorgan failure group of children had the youngest age (2.82±1.43) ranging from (1-1.6)
According to gender, the percentage of males in the study group was (40%) and Vs (60%) were females. The mean of serum NGAL was highest among the multiorgan failure group and was lowest among the control group. The multiorgan failure group showed significantly the highest means regarding CRP.
The platelet count is significantly low in the multi-organ failure group. TLC had
a positive correlation with risk of mortality and showed significantly highest means (23.97±6.67) in the multi-organ failure group.
Hemoglobin level was lower in the multi-organ failure group than in other groups, and also all discharged children from our PICU had some sort of anemia. Mortality was more in positive bacterial blood cultures than in blood cultures with no growth.
Liver function tests (ALT, AST, TB, and DB) were significantly higher among the Multiorgan failure group. Also, Renal function tests, (Urea and creatinine) were significantly higher among the multiorgan failure group. INR and PTT were highest among the multiorgan failure group.
CRP, INR, and PTT were significant predictors for serum NGAL and this result has a positive correlation with our study.
There were significant fair negative correlations between age, Ca, and Hb with serum NGAL.
Also, there were strong positive correlations between CRP, TLC, urea, TB, INR, and PTT with serum NGAL.
By the end of the study, we found that serum neutrophil gelatinase-associated lipocalin plays an important role in the prediction of the outcome of septic cases in PICU. The more the NGAL level, the more the severity of sepsis and the risk of mortality from sepsis. Serum NGAL has a significant prognostic value in sepsis.