الفهرس 
Cancer diseaseOnly 14 pages are availabe for public view
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Abstract
Cancer treatment has been a highly complex process. Chemotherapy is a widely used modality in treating cancers alone or in combination with other therapies, however, numerous adverse effects were developed due to increasing the oxidative stress agents and consequently led to toxicity of vital organs. Combination therapy of anticancer agents enhances efficacy compared to the mono-therapy approach because it targets key pathways in a characteristically synergistic or an additive manner. Natural antioxidants demonstrated potential tracking down free radicals and neutralizing their harmful effects thereby treating or preventing cancer. Annona sp. is a deciduous tropical evergreen fruit tree belonging to the Annonaceae family that has been widely used globally as a traditional medicine for several diseases. For instance, anticancer, antidiabetic, antiviral, antihypertensive, and wound healing Fifty grams of Annona sp fruits powder was mixed vigorously with 500 mL 70% (V/V) ethanol. The hydro-alcoholic extracts were filtered, and the solvents were dried under air condition. The Annona sp fruits extract (ASFE) was weighed and stored for processing. Total phenolic, flavonoids, total antioxidant capacity (TAC), free radical scavenging activity (DPPH), saponin, and the metal chelating activity were determined in the prepared extract by quantitative methods. Furthermore, phytochemical constitutes in ASFE were determined by gas chromatography mass spectroscopy (GC-MS) analysis.