الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
eukemia, a type of medullary blood cell neoplasm , is characterized by the clonal disorder of hemopoietic stem cells that suppresses differentiation hence cells accumulate at various stages of incomplete maturity , as well as reduced generation of healthy hemopoietic components.
Clinically , AML patients usually present with signs and symptoms related to bone marrow infiltration by leukemic blasts resulting in disruption of normal hematopoiesis with manifestations of infections, anemia, and thrombocytopenia.
The major extracellular matrix receptor ITGA7, one of the prevalent members of the integrin family, delivers signals from the extracellular matrix to cells using its β1 chain. It has been found to promote the development of various carcinomas through a number of different mechanisms.
The present study aims to explore Integrin alpha 7 gene expression in denovo acute myeloid leukemia and its relation to disease characteristics and response to induction chemotherapy.
This study was conducted on 80 subjects subdivided into 40 newly diagnosed non M3 AML patients and 40 healthy subjects as a control group.
Full history taking, thorough clinical examination, CBC, bone marrow examination at diagnosis, immunophenotyping , liver and renal functions were done to all cases. Follow up CBC and bone marrow examination were performed at day 28 postinduction chemotherapy.
Quantitative Real time PCR was performed for detection of ITGA7 mRNA , where ITGA7 gene expression demonstrated significantly higher level in AML patients with a median value of 2.0 (0.99 – 3.22) compared to normal controls. ITGA7 over expression correlated with lower CR achievement and shorter OS in AML patients.