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Abstract The main objective of this study is to evaluate the effectiveness of HRCT chest and pulmonary angiography in the identification of different causes of chest pain in persons with oncological diseases. A cohort of 120 individuals with oncologic conditions and chest pain were included in this analytical observational study. The study included the enrollment of individuals who were referred from both inpatient departments and outpatient clinics. All individuals underwent high-resolution computed tomography (HRCT) and computed tomography pulmonary angiography (CTPA) as part of the diagnostic procedure. This study aimed to assess the primary causes of chest discomfort, finding that pleural effusion was the most prevalent etiology, followed by pneumonia and pulmonary embolism. The findings of our study indicate a notable prevalence of physical exercise (PE) in patients diagnosed with colon and breast cancers. However, the incidence of PE was comparatively less frequent in individuals with hematolymphoid, female genital tract, urinary tract, and central nervous system (CNS) cancers. The manifestation of chest discomfort and dyspnea functioned as indicators for the onset of pulmonary embolism in patients diagnosed with cancer. The findings of our study indicate a notable discrepancy in cancer treatment and D-dimer levels between those who have been diagnosed with pulmonary embolism and those who have not. The sensitivity of the D-dimer test was determined to be 95%, whilst its specificity was computed to be 99%. |