الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Heterocyclic compounds present themselves as a fundamental division of organic chemistry. Among the various clinical applications, pharmacologically active heterocyclics have a remarkably active role as anticancer, analgesics, hypnotics and antidepressants drugs.1 A good number of heterocyclic compounds also find applications as pesticides, weedicides, rodenticides, and insecticides. Besides, heterocyclic compounds are essential diet components such as thiamin (vitamin B1), riboflavin vitamin B2) pyridoxol (vitamin B6), nicotinamide (vitamin B3) and ascorbic acid vitamin C). In other words, the chemistry of heterocycles is the heart of drug discovery and design.2, 3Recently, nitrogen-containing heterocyclic compounds have obtained a great attention of medicinal chemists and biologists due to an extensive range of pharmaceutical activity and numerous applications in various fields of pharmacy.4 Nitrogen-containing heterocyclic compounds not only form key structural in phytochemical drugs such as codeine, morphine, vinblastine, reserpine, procaine papaverine, emetine and cardiac glycosides like those of digitalis but also exist plentiful in synthetic drugs like diazepam, isoniazid, chlorpromazine, metronidazole, barbituric acid, captopril, chloroquinine, azidothymidine and antipyrine. In addition, most of the enzymes, co-enzymes, hormones, vitamins, nucleic acid and alkaloids have these important skeletons.5 Some analogues of new isosteviol-fused pyrazoline, ursolic acid linked triazole or D-ribose linked show anticancer effect at the nanomolar range. 6 Besides having fragment similarity with histidine imidazole compound can bind with protein molecules with ease as compared to some other heterocyclic skeletons. For this reason, these types of N-containing heterocyclics are the most promising ones in cancer research.