الفهرس 
AXIAL SPONDYLOARTHRITISOnly 14 pages are availabe for public view
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Abstract
A
xial spondyloarthritis (axSpA) is a chronic, immune-mediated inflammatory disease manifesting as a spectrum of inflammatory conditions, including inflammatory back pain (IBP), peripheral arthritis, enthesitis, extra-articular involvement, and comorbidities.
Axial SpA encompasses both radiographic axial SpA (r-axSpA), and non-radiographic axial SpA (nr-axSPA), which are differentiated based upon the presence or absence of radiographic sacroiliitis, respectively.
This study aimed to study the demographic features, clinical manifestations and imaging characteristics of axial spondyloarthritis (axSpA) in a cohort of Egyptian patients and to assess occurrence and differences between r-axSpA and nr-axSPA.
This cross sectional study was conducted on 80 patients who fulfilled the ASAS classification criteria for axSpA collected from Rheumatology outpatient clinic of Ain Shams University hospitals. Patients were further classified as r-axSpA or nr-axSpA based on radiographic findings according to modified New York classification criteria for AS.
All Patients were subjected to detailed medical history, assessment of disease activity, laboratory investigations & imaging.
Results of this study were compared with other studies performed across different regions of the world. Similarities and differences were obtained between Egyptian patients and others.
These findings can aid to recognize different characterstics along the course of the disease, similarities and differences between r-axSpA & nr-axSpA, risk factors affecting radiographic progression & factors affecting response to treatment. Thus, different modalities of treatment and even prevention of progression and complications can be performed.
This study shows that the majority of r-axSpA patients were males while the majority of nr-axSpA patients were females. There is a statistically highly significant difference between both groups regarding smoking so that it can be considered a risk factor for radiographic progression of axial SpA.
There is no significant difference between both groups regarding co-morbidities, age at onset of symptoms, type of first symptoms, age at diagnosis, peripheral arthritis, extra-articular manifestations & family history. There is a statistically highly significant difference between both groups regarding hip arthritis being more present in r-axSpA.
There is a statistically significant difference between r-axSpA & nr-axSpA patients regarding disease activity scores (ASDAS, BASDAI) & highly significant difference regarding (BASFI) being higher in r-axSpA.
There is no significant difference between both groups regarding type of received drug & HLA-B27.
By comparing both groups, the modified Stoke Ankylosing Spondylitis Spinal Score (mSASSS) was higher in r-axspa patients compared with nr-axspa with a highly statistically significant difference.
CONCLUSION
• This study aimed to study the demographic features, clinical manifestations and imaging characteristics of axSpA in a cohort of Egyptian patients and to assess occurrence and differences between r-axSpA and nr-axSPA.
• This study recognized disease characteristics in Egyptian patients and compared them with other patients across the world.
• Additionally, this study showed the differences and similarities between r-axSpA and nr-axSPA patients and factors affecting disease progression so that can help different modalities of prevention and treatment.
• Both groups are nearly similar regarding co-morbidities, age at onset of symptoms, type of first symptoms, age at diagnosis, peripheral arthritis, extra-articular manifestations, family history, type of received drug & HLA-B27.
• Both groups are significantly different regarding sex, smoking, hip arthritis, disease activity scores (ASDAS, BASDAI & BASFI) and mSASSS
RECOMMENDATIONS
• Early diagnosis & treatment of axial SpA should be considered to lower disease activity, improve patients quality of life and prevent radiographic progression and complications.
• Some risk factors for radiographic progression of axial SpA are modifiable so further progression can be prevented.
• Further studies on large scale needed to be performed