الفهرس 
Biological BehaviorOnly 14 pages are availabe for public view
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Abstract
Title: preoperative versus postoperative radiotherapy in patients with soft tissue sarcoma in extremities: wound and local complications a randomized comparative clinical trial
Ziad Khaled Abdallah1. Ayman Mohammad EL Masry1. Sherif Ishak Azmy1. Mohamed Ahmed El Mowafi1. Mohamed Abdel Rahman Mustafa1
Abstract
Background and purpose:
Radiotherapy is considered a cornerstone as adjuvant or neo adjuvant to surgery in ESTS (extremity soft tissue sarcoma). Wound complications are the most agonizing complication that may have an impact on patient’s functional outcome following radiotherapy. Our aim is to get the technique that facilitates safe surgical resection with the best functional outcomes. We also aim to detect the complications that result from radiotherapy and analyze if it affects the surgical wounds in way that may prevent using one of the techniques of radiotherapy.
Patients and methods:
between January 2021 and June 2022, we prospectively included 22 patients and categorized them into two groups, group A (preoperative radiotherapy) and group B (postoperative radiotherapy). We included patients with extremity soft tissue sarcoma in skeletally mature patients who were randomized into two groups with follow up 9 – 12 months. Wound complications, local complications, recurrence, time for wound healing and survival rate were recorded and analysed using SPSS 25.
Results:
22 patients were included, 10 in group A and 12 in group B, their mean age was 46.4 years with mean follow up 9 months. The major wound complications were higher in group A (preoperative radiotherapy). However, it does not reach statistical significance in comparison with group B (postoperative radiotherapy). While other local complications were higher in group B, it was also statistically insignificant. Time for wound healing was higher in group A more than group B and was statistically significant (p value = 0.011)
Conclusion:
we believe that there is no increase in the wound complications rate between preoperative and postoperative radiotherapy by using low fractionated doses of radiotherapy and increase interval before surgery to six weeks, while there is delay in wound healing time after surgery, but the size and site of the tumor may increase the risk of wound complications unrelated to type of radiotherapy.