الفهرس 
AcknowledgmentOnly 14 pages are availabe for public view
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Abstract
he SARS-CoV-2 virus has caused a global crisis, with Molnupiravir (MLN) being the first approved antiviral drug for nasopharyngeal infection. This study aims to determine MLN and its main degradation product and metabolite using a sensitive, simple, and green HPLC-DAD method. The method was applied under various stress conditions, including NaOH, HCl, neutral, H2O2, dry heat, and sun light. MLN was found to be highly vulnerable to alkali hydrolysis, while stable under oxidative, neutral, and sunlight-induced deterioration. The LC-MS-UV method was used to suggest the stress-induced degradation route and characterize the eluted degradation products. Toxicities of both MLN and its degradation products were evaluated using ProTox-II and they were found to be negligibly harmful. The proposed HPLC-DAD method was effective for MLN analysis in commercial pharmaceutical formulations, with superior results after greenness and whiteness appraisal.