الفهرس 
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Abstract
Diarrhea is considered one of the most common diseases that affect human health, despite the progress in prevention and treatment. The prevalence of chronic diarrhea has been found to be between 1% and 5% in the adult population and between 7% and 14% in the elderly population There is a wide range of problems that can cause chronic diarrhea. It can be divided into the main causes that include (infectious causes and non-infectious causes) and other causes that include (poor sanitation, malnutrition, malabsorption, inflammatory bowel disease, bile acidemia, celiac disease, microscopic colitis, and various other causes) The most important causes are bacteria Bacterial Escherichia coli. There are six known species of enteropathogenic E. coli: enteropathogenic E. coli (EPEC), Shiga toxin-producing E. coli (STEC), enteropathogenic E. coli (ETEC), enteropathogenic E. coli (EAEC), and enteropathogenic E. coli (EIEC). and disseminated adherent Escherichia coli (DAEC). These E. coli strains also cause gastrointestinal diseases ranging from self-limiting diarrhea to ulcerative colitis This study was trying to identify the infectious causes of functional and organic diarrhea, the pattern of antibiotic sensitivity of the causative microbes and the value of the molecular diagnosis using multiplex PCR by the BioFire Film Array GIP.The advantages of using the BioFire FilmArray GI panel resulting in a significant reduction of unnecessary isolation days, antibiotic therapy and prevention of additional diagnostic procedures in patients with clinical suspicion of infectious gastroenteritis This study was a hospital-based descriptive cross-sectional study. The study included 92 patients. The study was conducted on 92 patients suffering from chronic diarrhea who were recruited from Al-Rajhi Liver Hospital, Assiut University Hospitals. This study was conducted in the Microbiology Unit of the Department of Clinical Pathology at Assiut University Hospital during the period of one year (2020-2021). Demographic data including age, sex and occuption were recorded. The laboratory investigations, stool cultures and molecular diagnosis were done according to SOPs of microbiology laboratory.