الفهرس 
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Abstract
Vitiligo is a devastating autoimmune depigmenting skin disease. Vitiligo patients mostly report decreased quality of life; as it can be disfiguring, and also due to lack of curative treatments till now (Alikhan et al., 2011).
No single cause for vitiligo has been identified, though factors such as genetics, stress, metabolic alteration, and oxidative imbalance(Wang et al., 2019). Autoimmunity also has been powerfully proposed, and now it is supposed that different mechanisms converge to induce the disease (integrated theory) (Bellei et al., 2013).
Mortalin is a predominantly mitochondrial member of the Hsp70 family of proteins. Mortalin has different functions including import of nuclear-encoded proteins into the mitochondrion, protein folding, oxidative stress response regulatory function, intracellular transport, chaperonization, and protection against apoptosis (Wadhwa et al., 2002). Recently, mortalin has been shown to be involved in oxidatively stressed cells, and also in melanogenesis (Wadhwa et al., 2016).
Our study was conducted in Dermatology outpatient clinics, Suez Canal University hospital in Ismailia. The studied group consisted of 20 patients with non-segmental vitiligo, aging above 18 years of both genders. Demographic and clinical data from each patient was recorded. Vitiligo disease activity and severity were assessed by using the VIDA score, and VES score.