الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths throughout the world. In spite of the aduvent of multimodality approaches to the management of CRC, the global burden of CRC is expected to increase up to 60% by 2030.
Cancer stem cells (CSCs) are thought to be closely related to the occurrence and development of tumors. The CSC hypothesis considers that many cancers are not mere monoclonal expansions of cells but might actually be akind to abnormal organs, sustained by a diseased CSC population. Therefore, to find and study the genes that regulate CRC cell stemness may be considered a potential therapeutic approach for CRC. Among CSC markers, CD 44 and OPN which used in several studies in various lesions benign and malignant.
We evaluate in this study the relation between expression of CD44 & Osteopontin (OPN) in colorectal adenoma and adenocarcinomas (NOS) and their relation with clinic-pathological prognostic criteria of the disease by using IHC technique