الفهرس | Only 14 pages are availabe for public view |
Abstract Rheumatoid Arthritis (RA) is a chronic, progressive, inflammatory, autoimmune disease that could be disabling throughout its course. It affects people in their most reproductive years with relatively high morbidity and mortality. The exact etiology of RA is yet to be fully understood. However, genetic and environmental factors and their interplay are always named as culprits. As epigenetic field of study represents this interaction, it had become particularly interesting to researchers to find susceptible epigenetic factors and potential future therapeutic targets. Long non-coding RNAs became one of those epigenetic mechanisms to prove a link to RA pathogenesis and development, including H19 and MALAT1 genes. Both genes are present on chromosome 11 and their expressions had proved to increase in multiple diseases, attracting attention to their polymorphisms and their possible risk role. In this study, 200 hundred subjects (100 RA patients and 100 healthy controls) were investigated for a possible link between the polymorphisms H19 SNP (rs2251375) and MALAT1 |