الفهرس 
The Biological EvaluationOnly 14 pages are availabe for public view
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Abstract
Synthesis of Some New Diethyl α-Aminophosphonate Derivatives
Bearing Bioactive Heterocycles as Antiagricultural Pests
We displayed the synthesis of some novel bioactive quinolinyl,
chromonyl and 1,3-diarylpyrazole α-aminophosphonate esters clubbed with
nitrogen heterocycles in one molecular frame which showed enhanced
biological activity. The methodology depended on the design of these novel
α-aminophosphonates scaffold by one-pot three-components of aldehyde,
amine and diethyl phosphite in the presence of CdI2 nanoparticles as an
efficient catalyst under conventional at 80 oC or ultrasound (US) irradiation
at 50 oC. All obtained products were characterized by spectroscopic methods
and elemental analysis. In addition, all the synthesized products were
evaluated in vitro for their antifungal activities.
Part I: Design of Novel Quinolin-4-one α-Aminophosphonate
Derivatives Under Ultrasonic Irradiation Using CdI2 Nanoparticles as
an Efficient Catalyst: Synthesis, characterization and Antifungal
Properties
Two series of ten novel α‐aminophosphonate esters 2a-e, 4, 6, 8, 10 and
12 that incorporated 4-oxo-quinoline moiety, were designed by the
Kabachnik–Fields reaction. Diethyl {(4-oxo-1,4-dihydroquinolin-3-yl)
(arylamino)methyl}phosphonates (2a-e) were obtained in excellent yields by
reaction of 4-oxo-1,4-dihydroquinoline-3-carboxaldehyde (1) with different
substituted anilines and diethyl phosphite under conventional at 80 oC or
ultrasound (US) irradiation at 50 oC in the presence of CdI2 nanoparticles (10
mol%) (Scheme 1)