الفهرس 
INTRODUCTIOOnly 14 pages are availabe for public view
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Abstract
Osteoarthritis is a slowly progressive and devastating disease with high frequency in
adult population.One of the most affected joints is knee by this disorder and there is a great
function loss generated and lowering of quality of life of those osteoarthritic patients. The
prevalence estimation of OA is about 70% in women and 60% in men over 65 years.
Osteochondral defects usually progress to joint degeneration, characterized by loss of
flexibility stiffness and pain. There is a limited possibility of healing of articular cartilage as it
is not vascularized, making the treatment become a challenge. The injury of chondrocytes, No
hematomas are formed, no fibrin nor form a clot, only there is a support for tissue repair and
restricting the inflammatory response
Pharmacological approaches for treatment of OA, currently, aim to reduce inflammation
and pain, correcting joint function, and slowing disease progression. Medicines which are
frequently used in OA treatment include non-steroidal antiinflammatory drugs (NSAIDs),
steriods and disease-modifying OA drugs (DMOADs). All these treatments are accompained
with a high rate of side effects, as heart failure and gastrointestinal damage.
The goal of therapies for OA nowadays, is to relief painful symptoms of the disease
with minimum side effects , Alginate is a naturally occurring biocompatible agent, which
have a lot of clinical uses in different fields, and has favorable effects on chondrogenesis and
cartilage regeneration.
Our study was done to weigh up the effect of brown algae extract (Alginate) on
osteoarthritic induced male rats with mono-iodo acetate ( MIA). The present work was done
on seventy-seven male rats divided into three groups, group I (28 rats) as control group.
group II (28 rats) as inducted group by MIA. group III (21 rats), treated group by weekly
alginate dose after induction.
Biochemical and histopathological results have showed after MIA induction , a significant
increase in MMP-3 and beta- glucuronidase levels, an increase in ACP and MDA levels, while
showed a significant decrease in GSH levels. Meanwhile, after alginate treatment on osteoarthritic
induced rats , there was a decrease in the levels of MMP-3, ACP, beta- glucuronidase and MDA,
while showed a marked increase in GSH level , the histopatholgical results after alginate
treatment increased intensity of chondroid matrix , no cracks nor fissures and decrease in oedema
of cartilaginous matrix and no rarefaction of articular surface, preservation of lobular
chondrocytic array and no denudation of articular surface.