الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
DR develops in the eye due to microangiopathy that occurs elsewhere in the body. When it comes to DR, macular non-perfusion is the most concerning indication since it can cause severe vision loss. Patients with diabetes who have poor macular perfusion are generally asymptomatic until the disease has progressed to a point where they are experiencing sudden and severe vision loss. This is because microvascular dysfunction in DR generates hypoperfusion, retinal hypoxia, and in the macula it threatens the tissue responsible for central visual acuity.
The advantages of therapy may also be diminished in advanced cases of macular non-perfusion. Therefore, early detection and measurement of these microvascular alterations can avert vision loss.
Fundus photography and fundus fluorescein angiography (FFA) are two procedures that ophthalmologists have used to investigate the macular region’s vasculature. However, the intrusive nature of these techniques means they have their limits. The clinical monitoring of early and subtle alterations in the retinal capillary system has also been difficult. Therefore, it would be simple and straightforward to interpret and see early perfusion changes if there were a reliable, high-resolution, and non-invasive technology for monitoring retinal perfusion.
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