الفهرس 
Other inherited risk factorsOnly 14 pages are availabe for public view
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Abstract
Pancreatic cancer is an intractable malignancy and is the seventh leading cause of global cancer deaths in industrialized countries, and the third most common in the USA (1). Based on GLOBOCAN 2020 estimates, pancreatic cancer has ranked the 12th most common cancer in the world counting 495,773 new cases and causing 466,003 deaths in 2020. Worldwide incidence and mortality of pancreatic cancer correlate with increasing age and is slightly more common in men than in women (1). In Egypt, according to incidence rate; the pancreatic cancers are the 11th most common malignancies and represent 2.2% of all cancers incidence .While according to mortality rate, pancreatic cancers are the 8th of all deaths caused by cancer and represent 3.2% (1,2). In Gharbiah, pancreatic cancers account for 3.2%of malignancies in males versus 1.6% in females (3). The percentage of death certificate only (DCO) cases is comparable between the Gharbiah Population-Based Cancer Registry(GPCR) (5.5% in men and 4.7% in women), compared to the Surveillance Epidemiology and End Results (SEER) registries (2.5% and 3.4%, respectively) (4). Biliary tract cancers (BTC) represent the second most common type of hepatobiliary cancer worldwide, and are typically classified as intrahepatic cholangiocarcinoma (iCCA), perhilar/hilarcholangiocarcinoma (pCCA), distal cholangiocarcinoma (dCCA) and gallbladder cancer (GBC) (5).