الفهرس | Only 14 pages are availabe for public view |
Abstract Results: we had 48 subjects, where we had 24 autistic child and similar age and gender matched controls, with median (IQR) age of 5.25(5 – 8) and 6(5 – 9) years respectively, where we had a male predominance (68.75%). The median serum level of IL-17A and IL-22 were significantly higher in autism patients than controls, where serum level of IL-17 was 262.5 (235 – 320) pg/mL in autistic patients versus 35 (25 – 47.5) pg/mL in controls, meanwhile IL-22 in autistic patient was 800 (680 – 975) pg/mL versus 50 (45 – 65) pg/mL in controls (p=<0.001). Conclusion: Our findings suggest that elevated levels of IL-17A and IL-22 may be associated with autism. Further research is needed for better understanding the role of these cytokines in autism and their potential implications for diagnosis and treatment. |