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العنوان
Aspirin – inspired nano-organometallic compounds derivatives: preparation, spectroscopic characterization and
/ biological properties.
المؤلف
Ahmed, Reham Ali Saied
هيئة الاعداد
باحث / ريهام على سيد أحمد هشهش
مشرف / عبده سعد الطبل
مشرف / عبدالحميد اسماعيل
مشرف / سوسن عبد الهادي محمود حسن
الموضوع
Chemistry
تاريخ النشر
2023
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
Analytical Chemistry
تاريخ الإجازة
30/10/2023
مكان الإجازة
جامعة المنوفية - كلية العلوم - قسم الكيميا ء
الفهرس
Only 14 pages are availabe for public view

from 289

from 289

Abstract

English Summary
This work is composed of aim of the work and three main chapters
Aim of the work
The work aimed to prepare and characterize new aspirin metal complexes to study their biological activity against bacteria and fungi hoping to explore some effective compounds to be used in treatment of some microbial diseases.
I- Introduction
This chapter includes an overview of previous researches for ligand metal complexes and their applications.
II- Experimental
This chapter contains the chemical and instruments used in Practical part of thesis as follow:
1) Preparation of the ligand and its metal complexes.
2) Characterization of the ligand and its complexes using:
• Physical techniques such as molar conductance, magnetic susceptibility and melting point.
• Elemental analyses (C, H, N, Cl and M).
• Spectral techniques as IR, UV-Vis., 1HNMR, mass spectra and ESR measurements.
• Thermal techniques as DTA and TGA
3) Measurement of Antibiological activity.

III- Results and discussion
This chapter includes characterization of the ligand and its metal complexes. The complexes were prepared and characterized by elemental analyses, IR, UV-Vis spectra, Magnetic moments, Conductivity, 1H-NMR and Mass spectra, Thermal analyses (DTA and TGA) and ESR measurements.
The elemental analyses, spectral data reveal that, the formed complexes are colored, stable in the air and soluble in solvents such as DMF, DMSO and ethanol.
The antibacterial activity was tested against two bacterial strains; Gram-positive Staphylococcus aureus as well as Gram-negative Escherichia coli strains. The complexes were also subjected to antifungal activity against Aspergillus flavus and Candida albicans. Complex (10) and complex (25) appeared in nano size and shows high activity against bacteria and fungi.