الفهرس 
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Abstract
Summary
Acne vulgaris (AV) is a common chronic inflammatory skin disease involving pilosebaceous follicles characterized by comedones, papules, pustules, nodules, and sometimes scars. AV is a multifactorial disease in which several factors have been implicated, including hormonal effects, follicular hyperkeratinization, proliferation of propionibacterium acnes, inflammatory, environmental factors and genetics. Acne vulgaris affects not only the skin but it may also be connected with metabolic abnormalities, including glucose intolerance and lipid abnormalities, all of which confirms the systemic nature of the disease.
Interleukin-17 is a family of six cytokines that includes IL-17A through IL-17F. It has diverse biological functions, but the best characterized functions relate to its proinflammatory effects. It is involved in some other diseases as airway inflammation, peritoneal inflammation, rheumatoid arthritis, inflammatory bowel disease, demyelinating disorders, allograft rejection, inflammatory diseases of skin and cornea and tumour growth. It has been suggested to have a pivotal role in the pathogenesis of different skin diseases.
We aimed to evaluate serum IL-17 level in AV patients as an attempt to answer the question about its role in disease pathogenesis, severity, and development of scarring lesions. This case-control study
was carried out on 50 patients with different degrees of acne vulgaris severity (group A) recruited from the Outpatient Clinic of
Dermatology Department of BeniSuef University Hospitals in
addition to 30 age and sex matched healthy volunteers as a control group (group B).
To the best of our knowledge, the present study is the one of the few studies to evaluate IL-17 levels in AV patients aiming at understanding etiopathogenesis of the disease. For all participants, thorough history taking and good general and dermatological examination were done. In addition, serum levels of IL-17 were tested.