الفهرس 
COPD pathogenesisOnly 14 pages are availabe for public view
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Abstract
Background:
COPD patients have a higher risk of developing CKD than the general population. [Chen and Liao 2016 ]
Age, diabetes, arterial hypertension and overweight are the most common risk factors for new onset of CKD.
The pathogenesis of CKD includes atherosclerotic damage, due to activation of pro-inflammatory and pro-oxidant pathways leading to pathologic changes in renal circulation [Pelaia,et al 2020]
Pulmonary cells can produce many cytokines,that reach the systemic circulation and target other organs, and can also produce inflammatory effects. [Barnes, 2009]
The aim of the study:
To Predict the impairment of renal functions in Patients with chronic Obstructive Pulmonary Disease (COPD).
Patients and methods:
The study was carried out during the period from March 2022- February 2023 on one hundred patients with COPD during their follow up in the outpatient clinic or admission at the chest department, Fayoum University hospital.
All patients in this study will be subjected to full medical history, clinical examination, BMI, spirometry, chest x-ray, blood pressure, glycated hemoglobin, fasting plasma glucose (FPG), 2 h postprandial glucose , triglycerides, total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), albumin, creatinine, uric acid, eGFR, and urine analysis .
Results:
-There was a colleration between FEV1 and Creatinine in COPD patients during the study. (P: 0.019). (P<0.05)
-There was no significant colleration between uric acid and FEV1
(P: 0.359 ) or with COPD class (P:0.477)
-There was no significant statistical colleration between FEV1 or classes of COPD patients as regard (eGFR) (P:0.095 , 0.554).( P<0.05) respectively.