الفهرس 
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Abstract
Perimenopausal depression is a common and complex problem that carries an increased risk of morbidity and affects high sectors of women. Identification of perimenopausal depression is very crucial because proper detection and evaluation of it and prompt intervention can result in a healthy menopausal transition and hence healthy menopause leads to an improvement in quality of life.
Objective: To assess the prevalence of perimenopausal-related symptoms and to evaluate their impact on quality of life (QoL) among 350 perimenopausal women from Egypt from 1 June 2022 to 1 June 2023.
Materials and Methods: A cross-sectional hospital-based study conducted at the Gynecology Department, EL-Shatby Maternity Hospital, Alexandria University, Egypt. A total of 350 women aged 45-55 years were recruited and studied using an interview questionnaire. The questionnaire contains four main items: socio-demographic data, menstruation status assessment, patient health questionnaire 9 (PHQ-9), and Personal well-being Index – adult (PWI – A) questionnaire.
Results: Mean age was (47.48 ± 3.0), with (52.6%) of the studied participants being from rural environments and. 52% of the participants were from Alexandria and (48%) were outside Alexandria. about (27.1%) had a middle-level education while (72.9%) had a higher level of education. About (55.4%) of all participants had a job, while (44.6%) were housewives. (87.4%) of all participants were married, (14.9%) of all participants had a high-income level, while about (48.6%) had a moderate level and about (36.6%) had a low-income level. About (13.4%) of all participants were nulliparous, while about (9.7%) were primiparous, and about (76.9%) were multiparous. (38%) were premenopausal, while (62%) were perimenopausal.
• Regarding perimenopausal women:
o About (20.2%) had (none or minimal depression).
o About (31.3%) had mild depression.
o About (27.2%) had moderate depression.
o About (12.4%) had moderately severe depression.
o About (8.7%) had severe depression.
The Perimenopausal women have significantly higher scores on PHQ-9 than the premenopausal group.
They also had significantly lower QOL scores in all domains of PWI-A. PHQ-9 total score has a significantly strong negative correlation to all domains of the PWI-A questionnaire.