الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Colorectal cancer (CRC) is the third most frequent cancer and the second leading cause of death due to cancer, for men and women, in the world. The great majority of CRC cases are sporadic (70% to 80%), a subset have a hereditary component, and another subset may occur as a consequence of inflammatory bowel diseases.
The human body is inhabited by large communities of microorganisms–the microbiota that together with their genome and the niche with which they interact constitute the microbiome. The microbiome plays an important role in the normal human physiology, and alterations to the microbiome–host homeostasis, also known as dysbiosis, can affect the development and progression of several diseases, including cancer.
The aim of the present study is to identify the gut microbiome that are likely related to CRC. This may have an impact on future understanding of pathogenesis of the disease and possible approaches to prevent and treat it. Also study of the difference in gut microbiome between CRC patients as regards disease site, extent and histopathology.
The study included 40 CRC patients from Alexandria University Hospital and 40 healthy controls with matched age and sex. Stool specimens were taken from all participants. Quantitative SYBR Green Real-Time PCR technique targeting 16S rRNA was done for the identification and quantitation of selected bacterial phylum, genera and/or species.