الفهرس 
Parkinson’s diseaseOnly 14 pages are availabe for public view
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Abstract
Background: PD reflects pathological increase in oxidative stress and inflammation-related events. Being neuroprotective, ApoD was found to be upregulated in brains affected with PD. This work aimed to detect ApoD level in PD in comparison to control group and correlate it with clinical data and VEP. Patients and Methods: Thirty patients with idiopathic PD were subjected to neurological examination, assessment of disease severity using(UPDRS , H & Y and SE-ADL scales),visual evoked potential assessment and measurement of ApoD serum level. Thirty ages and sex matched controls were included for comparison of ApoD serum level .Results: The level of ApoD was significantly higher in patients than the control subjects. There was a significant positive correlation between ApoD serum level and UPDRS and H & Y scales. Significant negative correlation was found between the ApoD serum level and SE-ADL scale. P100 latency was significantly delayed with lower amplitude in PD patients than the controls group. P100 latency was positively correlated with ApoD and disease severity. Conclusion: PD patients have higher serum ApoD level, more delayed P100 latency, and both positively correlated with disease severity.
Key words: PD, ApoD, VEP.