الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Acute pancreatitis (AP) is an acute inflammatory process in which the pancreatic injury can remain localized, spread to nearby tissues, or lead to systemic inflammation through the activation of cytokine cascades. characterized by autodigestion of the pancreatic parenchyma, interstitial fat necrosis and necrotizing vasculitis, resulted from the inappropriate intracellular activation of proteolytic pancreatic enzymes. The inflammatory process may be limited to the pancreas, spread to surrounding tissues or even involve the remote organs, resulting in multiorgan failure and occasional death. The incidence of acute pancreatitis continues to increase worldwide, and it is one of the most common gastrointestinal causes for hospital admission in the USA. The two most common causes of acute pancreatitis are gall-stones (30 - 45%) and alcohol abuse (30-35%), Less common causes include hypertriglyceridemia, hypercalcemia, viral infections (mumps, coxsackie), biliary parasites (ascaris), drugs (azathioprine, mercaptopurine, didanosine), oddi dysfunction, tumor, trauma, surgery, endoscopic retrograde cholangiopancreatography (ERCP) and congenital abnormalities (pancreas divisum , annular pancreas, chole-dochocele, duodenal duplication cyst). Acute pancreatitis is idiopathic in up to 20% of all cases, although about two-thirds of these cases are now thought to be caused by biliary sludge or microlithiasis. Local complications of acute pancreatitis should be suspected when there is persistent or recurrent abdominal pain, secondary increase in serum pancreatic enzymes, development of fever or leucocytosis, and increasing organ dysfunction. Local complications include acute peripancreatic fluids collections, pancreatic pseudocysts, acute necrotic collections (ANC), walled off necrosis (WON). And the inflammation may proceed to cause: Systemic complication such as organ failure and its consequences are well recognized in AP, there is limited understanding about primary of that develops early due to (sterile inflammation) (SIRS): systemic inflammatory response syndrome and may precede necrosis, and late secondary of due to infected pancreatic necrosis (IPN) induced sepsis. This study aimed to assess Triglyceride and glucose (TyG) index as an effective marker to identify severity of acute pancreatitis. This prospective cohort study was carried out on 60 patients admitted with acute pancreatitis at the internal medicine department Tanta university hospital in a period from November 2021 to December 2022 and may extend. Patients with acute pancreatitis were divided into two groups: severe group (n=17) and non-severe group (n=43).