الفهرس 
Hepatocellular carcinomaOnly 14 pages are availabe for public view
 |  | from | 169 |  |  |
| | | from | 169 | | |
Abstract
This prospective cohort study was conducted to evaluate the prognostic role of NLR and PNI in patients with HCC who underwent transcatheter arterial chemoembolization (TACE).
Fourty patients with HCC were enrolled and evaluated based on laboratory and imaging data then they underwent TACE and were subjected to follow up for a month.
Exclusion criteria were : Patients who underwent hepatic resection, radio-frequency treatment, liver transplantation or another appropriate treatment for HCC during the follow up period. For all participants, the following was done: A. Full history taking.
B. Full clinical examination including: General and local examinations.
C. Laboratory investigations which included: CBC, liver profile (ALT, AST, albumin, total bilirubin, direct bilirubin, prothrombin time, concentration and INR),HBs Ag, HCV ab, renal function tests, AFP and serum Na.
D. Imaging: pelvi-abdominal ultrasound and triphasic CT abdomen.
The results of this study were as follows: 1. In the current study, the most common aetiology of liver disease was HCV infection. 2. Regarding follow up of patients after TACE; it was found that, (70%) of them had well ablated tumor while, (30%) patients had still active tumor. 3. Different NLR-PNI score groups had insignificant statistical diffrences as regard to age and sex.
4. There was no statistical significant difference as regard to number of HFL in triphasic CT between NLR-PNI score groups. 5. Results of TACE in follow up triphasic CT, in NLR-PNI 0 group (100%) of patients had well ablated tumor, in NLR-PNI 1 (60%) of patients had well ablated tumor and in NLR-PNI 2 (100%) of patients still have residual active tumor tissue. 6. High NLR and decreased PNI were associated with worse results of ablation in patients who underwent TACE for unresectable HCC. 7. At cut off point > 2.28, preoperative NLR had 83.33 % sensitivity and 96.43% specificity while, at cut off point ≤36 preoperative PNI had 83.33 % sensitivity and 82.14 % specificity for prediction of TACE results in unresectable HCC.