الفهرس 
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Abstract
all organ systems and particularly to the nervous system. It can take up to 72 hours for neurological manifestations to appear. Prolonged hypoxic conditions in newborn infants as a result of birth asphyxia will lead to impairment of blood flow to vital organs like the brain leading to brain injury which can manifest itself as a neurobehavioral state known as Hypoxic Ischemic Encephalopathy. Approximately four million newborn children die annually. Almost one quarter (23%) of these deaths are caused by perinatal asphyxia, most of them in developing countries.
Several studies have been carried out to try to correlate biochemical markers of perinatal asphyxia with its neurological consequences and stages of HIE. It was found that these biomolecules, especially LDH show significant rise in the initial perinatal period.
As a result this study is going to investigate if any correlation of Lactate Dehydrogenase (LDH), with the occurrence of different stages of HIE is present or not and how they are related with different stages of HIE in order to be able to use these enzyme as marker or predictor of HIE before the appearance of significant clinical features to allow earlier management of HIE and improve the mortality and morbidity rates due to it.
This study was an observational cross-sectional study conducted upon 60 newborns within 12h after birth in the neonatal intensive care unit and maternity ward of Suez Canal University hospital. The study participants were divided in two groups: Cases which were the newborns diagnosed with HIE due to perinatal asphyxia, and Controls which were healthy newborn that serves as control. The study aimed at evaluating the predictive value of salivary lactate dehydrogenase level, as a potential predictor of hypoxic ischemic encephalopathy for newborn. This study was carried out in the neonatal intensive care unit and maternity ward of