الفهرس 
ClusterinOnly 14 pages are availabe for public view
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Abstract
Pityriasis versicolor is a mild, chronic superficial infection of the stratum corneum layer of the skin caused by Malassezia furfur and/or other species of Malassezia. The genus Malassezia is part of the normal skin microflora, and it needs predisposing factors for multiplication and subsequent conversion from the commensal yeast form to the mycelial phase (pseudo-filamentous parasitic form) The lesions are characterized by discrete, serpentine, hyper or hypo- pigmented maculae developing on the skin; usually on the chest, upper back, arms, and abdomen. These lesions may enlarge and coalesce, but scaling, inflammation and irritation are minimal as the host response is minimal.
Clusterin (CLU) is a multifunctional glycoprotein that has secretory and nuclear isoforms. It is involved in the regulation of proliferation, differentiation and survival of cells. The common activating signal is likely to be oxidative stress and the consequent oxidative damage to proteins that alters their folding or introduce oxidative-inflammation conditions. Elevated clusterin expression improve cell survival by reducing the oxidative damage to DNA, proteins and lipids.
The goal of this study was to evaluate serum clusterin level in patients with pityriasis versicolor and assessment of its clinical significance in relation to metabolic syndrome components in those patients.
This study included 40 patients suffering from pityriasis versicolor. In addition to 40 apparently healthy individuals of matched age and sex as a control group. All studied individuals were
subjected to complete history taking and complete clinical examination. All patients were selected from the outpatient clinic of dermatology department of Benha university hospitals. The study was approved by the local ethics committee on research involving human subjects of Benha faculty of medicine. An informed consent was obtained from each individual before sample collection.
Results of the current work showed that mean serum level of clusterin in patients group was significantly lower than in control group. Also, serum TG was significantly higher in pityriasis versicolor patients than healthy controls.
Results of the current study showed that there was a significant positive correlation between serum clusterin level and total cholesterol, TG and LDL-C levels in patients with pityriasis versicolor.
However, there was no significant correlation neither between serum clusterin level and age or duration of disease among the studied patients.