الفهرس 
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Abstract
Background: In intensive care units (ICUs), mechanical ventilation (MV) can save lives, but
it is also associated with a variety of problems. Diaphragm dysfunction is considered one of
the major complications that may cause difficulties in liberation from MV, representing an
extensive burden in terms of MV duration, length of stay (LOS) in the ICU, morbidity,
mortality, and cost of care. Since phosphorus (P) is an essential element for cellular function,
it was found that hypophosphatemia can cause respiratory muscle weakness and prolonged
MV. Additionally, it was found that serum P level increase to 4.11 ± 0.65 in
hypophosphatemic mechanically ventilated patients with acute respiratory failure was
accompanied by a significant increase in the transdiaphragmatic pressure (Pdi), which was
recommended not only to avoid complications from respiratory failure but also to propably
wean off the ventilator.
Study objective: To conduct a prospective interventional study assessing the impact of serum
P level optimization to 4 ± 0.5 mg/dL on weaning from MV.