الفهرس 
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Abstract
Background: Thyroid hormone is an important regulator of fetal growth and rnal thyroid hormones during the first 18 to 20 weeks of pregnancy, but after that the contribution of maternal thyroid hormone remains considerable. In the first 7 weeks of gestation, fetal lung buds are formed, and from the fifth to approximately the 17th week of gestation, the development and branching of the bronchial tree and pulmonary artery system take place. In lungs from human fetuses, thyroid hormone receptor expression has been shown as early as 13.5 weeks of gestation. In vitro and animal studies have shown that, in the early developing lung, the administration of exogenous T3 leads to acceleration of epithelial and mesenchymal cell differentiation but reduces branching morphogenesis and lung growth. Patients and Methods: Cross - sectional study. Study duration : • The study was conducted between( August 2021 - March 2022 ). Study setting : • Mansoura University Children Hospital. Study subjects study was 60 atopic asthmatic patients compared to 30 healthy patients of matched age and sex. •Results: Cough, Increased sensitivity to cold and Nose allergic rhinitis were the most common complaints in the asthmatic group and were detected in 98.3%. •Thyroid disorders were reported in 20% of the asthmatic group and 5% of them had neck goiter. •Regarding the disease severity, 8.3% of children showed daily attacks and 11.7% had daily nocturnal attacks. •The TPO level was statistically significaly higher in the asthma group. •There was statistically significant negative correlation between Anti TPO enzyme level and T3. Skin test result among children with atopic bronchial asthma showed that, the most common allergen was mixed mites representing positive skin test among 38.3% of children followed by 31.7% for strawberry, mixed pollens. 1-Conclusion: Bronchial asthma is associated with hypothyroidism among the affected children which mostly due to autoimmune component evidence by higher level of Anti TPO enzymes. 2-The prevalence of thyroid disorders increased with the disease severity and associated with less response to treatment. Key Words: Anti -Tpo.