الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
The Conventional and Hypo-fractionated Radiotherapy protocol’s performance were compared in terms of the biological difference such as tumor control probability (TCP), normal tissue complication probability (NTCP), and equivalent uniform dose (EUD) were calculated, and the dosimetric difference such as homogeneity index (HI) and conformity index (CI). Thirty patients were selected, and the treatment plan was the intensity modulator radiotherapy (IMRT) technique. Utilizing the radiobiological model to compute the tumor control and normal tissue complications probabilities. The tumor control probability showed a significant difference in both protocols. and the conventional fractionated protocol presents more damage in the normal tissue than the hypofractionation protocol. Therefore, the hypo-fractionated schedule was more suitable characteristics to the patient. Material and Method: This study is a dosimetric and biological analysis of 30 randomly selected patients with high-risk prostate cancer. Each patient had a CT simulation performed, and two comparative treatment plans were created using the intensity modulator radiotherapy technique, one with a conventional protocol, the other with a hypo fractionated protocol then analyzed the DVH data by MATLAB. Result: For the PTVs, there was not a significant difference in V95%, maximum, mean, or median dose with hypofractionation and conventional. but The Minimum dose increased by 6% of the prescription dose in conventional. The CI and HI of hypofractionation are better than the conventional in all cases. There was a 14% difference between conventional and hypofractionation in TCP but there was not a significant difference in the EUD relative to the prescribed dose for hypofractionation and conventional. For OARs, D50%, median, mean dose of rectum and bladder was indicated low dose values in hypofractionation than conventional. Also, the hypofractionation offered better NTCP than conventional.