الفهرس 
Boosting of the dissolution behavior and bioavailability of dugs with poor solubility
Modulating Nimodipine Crystallinity for Enhancing Dissolution: Development of Geriatric-Friendly Dosage FormOnly 14 pages are availabe for public view
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Abstract
The dissolution rate of drugs is a determining factor for drug bioavailability after oral administration. This factor provides the main challenge in development and formulation of effective drug candidates. Now more than 40% of drugs in the development pipelines and about 60% of the drugs coming from synthesis suffer from low bioavailability after oral administration with poor drug dissolution being the main reason for this. Accordingly, scientists are probing many approaches to enhance drug dissolution rate. These include particle size reduction, microemulsification, micellar solubilization, co-solvency, complexation with suitable polymer, modulation of the chemical structure and formulation of solid dispersions with hydrophilic polymers.