الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Endocrine complications are common among children who have finished their cancer treatment program. Over the course of their lives, approximately half of those children will experience at least one hormonal disorder ). Therefore, screening for late endocrine effects is necessary to guarantee early detection and treatment of these side effects. The gender, age of the child at the time of the tumor’s diagnosis, tumor’s location and treatment modalities (surgery, chemotherapy, or radiation therapy), all affect the likelihood of developing an endocrine insufficiency. Growth hormone deficiency (GHD), thyroid abnormalities (primary or secondary), diabetes mellitus and hypogonadism (primary or secondary) are examples of endocrinopathies that can develop in those children. Aim of the study: To address the main endocrine abnormalities following cancer therapies that occur later in children for early recognition and better management of long-term endocrinal disturbances. Study design: It was a Cross sectional study conducted on seventy children who have completed cancer treatment at pediatric oncology unit of Oncology Center- Mansoura University from May 2022 to May 2023. Results: There was significant data regarding thyroid function. In that, 7.1% of studied group were detected to have hypothyroidism with significant difference in favor of exposure to radiation and developing hypothyroidism. About 60% of cases that developed hypothyroidism were exposed to neck radiation and the remaining 40% was exposed to nearby radiation to the neck denoting that children receiving radiation to the neck or nearby areas during their course of treatment should be subjected to continuous monitoring regarding thyroid function. Regarding diabetic predisposition, it was found that 7.1% of studied group have diabetic predisposition with no significant relation between treatment modalities and disease, but these patient were exposed to high doses of steroid during their treatment. Further studies with large number of patient and long term follow up duration are needed to investigate this side effect. The current study found that 8.5% of studied group have stunted growth with different history of cancer diagnosis (leukemia, neuroblastoma, soft tissue sarcoma and brain tumor).50% of these group were found to have GHD and the rest has normal GH provocation test. Conclusion: Endocrine complications are among the most prevalent late-effects in children cancer survivors which are represented by 21.4% in our study in the form of growth failure, hypothyroidism and diabetic predisposition. Radiotherapy was recorded as a major risk factor for developing hypothyroidism and GHD in cases exposed to neck and cranial radiation respectively. Also, chronic steroid use in cases of leukemia and lymphoma was associated with risk for diabetes development.